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Of key importance to the advancement of IGF targeting therapies in cancer is a comprehensive understanding of its role under normal physiological conditions

Emerging pathways of interest: Novel interactions identified in the PPI network suggest additional pathways requiring further investigation including ion transport regulation by genes like RHBG , which may influence tissue homeostasis

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No inhibition of the phosphorylation of p38 mitogen-activated protein (MAP) kinase, c-Jun N-terminal kinase (JNK), or extracellular signal-regulated kinase (ERK) was observed as a result of NAC-S2 treatment, suggesting that supersulfides specifically target NF-B signaling [77]

Hao Li, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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